Dr. Raphael Bueno

Dr. Raphael Bueno has had many successes in the medical field, including research and experience with treatment for malignant pleural mesothelioma.

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Dr. Raphael Bueno’s title as Chief of Thoracic Surgery is reflective of his expertise in this field. After earning his medical degree in 1985, Dr. Bueno has made many accomplishments in the medical industry, including his research and experience with malignant mesothelioma.

Professional History

Dr. Bueno started developing his professional career at Harvard Medical School, where he earned his medical degree (1985) and achieved many additional successes, including earning the Henry A. Christian award. He continued his professional development through graduate medical training at Brigham and Women’s Hospital (BWH), as an intern and then through surgical residency (1985 – 1993). At Massachusetts General Hospital, he completed a cardiothoracic residency (1993 – 1995), which transitioned into recruitment back to BWH to create a thoracic surgery practice and research facility.

Through his success in the medical field, Dr. Raphael Bueno is now not only the Chief of Thoracic Surgery, but also the co-director of the Brigham and Women’s  Lung Center, senior surgeon for BWH, Vice Chairman of Surgery for Cancer and Translational Research, Fredric G. Levin Distinguished Chair in Thoracic Surgery and Lung Cancer Research and professor of surgery at Harvard Medical School. His board certifications include those for General Surgery (1993), Surgical Critical Care (1993) and Thoracic Surgery (1997).

Major accomplishments of Dr. Bueno include conducting the first minimally invasive esophagectomies in Israel, leading the BWH thoracic team and helping inform the Israeli surgeons on how to conduct the procedures. Additionally, in 2013 he was the first to perform an Image-Guided Video-Assisted Thoracic Surgery procedure on a patient with lung cancer.

Clinical Interests and Research

His innovative approach to the medical field, growing medical knowledge and accomplishments have contributed to his specialized focus on mesothelioma, with clinical studies of malignant pleural mesothelioma, as well as some with malignant peritoneal mesothelioma.

Dr. Raphael Bueno’s Medical Areas of Interest
  • Airway management and surgery
  • Esophageal cancer
  • Lung cancer
  • Lung nodules
  • Mesothelioma
  • Swallowing problems

Dr. Bueno’s research has primarily focused on the development of novel translational tools in genomics for the purpose of predicting and identifying diagnostic markers for cancer, as well as developing novel targets for therapy for lung cancer and mesothelioma. He has sought to identify and understand cancers caused by asbestos, delve into their molecular structure and in doing so, discover more about how the disease reacts and responds to treatments.

In collaboration with other renowned researchers and doctors, such as Dr. Paul Sugarbaker and Dr. David Sugarbaker, Dr. Bueno has delved into a variety of publication topics, including a deeper understanding of mesothelioma on a cellular level, mesothelioma gene expression, the relation of genetic mutations with malignant pleural mesothelioma, molecular features of malignant pleural mesothelioma and the therapeutic and surgical effectiveness in addressing malignant pleural mesothelioma. With a deep understanding of malignant mesothelioma on a cellular level, Dr. Bueno has sought to find aggressive and highly effective treatments for the cancer through a variety of collaborative studies.

Selected Publications

Extrapleural pneumonectomy in the treatment of epithelioid malignant pleural mesothelioma: novel prognostic implications of combined N1 and N2 nodal involvement based on experience with 539 patients. Annals of Surgery. October 2014;26-(4):577-580. doi:10.1097/SLA.0000000000000903.

Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma. Cancer Research. January 15, 2016;76(2)319-328. doi:10.1158/0008-5472.CAN-15-0751.

Hypothermic intraoperative pleural cisplatin chemotherapy extends interval to recurrence and survival among low-risk patients with malignant pleural mesothelioma undergoing surgical macroscopic complete resection. Journal of Thoracic and Cardiovascular Surgery. April 2013;145(4):955-963. doi:10.1016/j.jtcvs.2012.12.037.

Sequential binary gene ratio tests define a novel molecular diagnostic strategy for malignant pleural mesothelioma. Clinical Cancer Research. May 1, 2013;19(9)2493-2502. doi:10.1158/1078-0432.CCR-12-2117.

Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues. Journal of Molecular Diagnostics. January 2017;19(1):65-71. doi:10.1016/j.jmoldx.2016.07.011.


Through his educational and professional successes, Dr. Raphael Bueno has earned accolades that are a testimony to his excellence.

  • Henry A. Christian Award – Harvard Medical School
  • “Boston’s Top Docs” of 2017 – Boston Magazine
  • “America’s Top Doctors” of 2017 – Castle Connolly’s Top Doctors