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David H. Harpole Jr. M.D.

  • Associate Professor of Surgery
  • Thoracic Oncology Program Duke University Medical Center
  • 919-668-7157

David H. Harpole graduated with a double Bachelors of Science from Washington and Lee University in 1980. He received his Medical Degree from the University of Virginia School of Medicine in 1984. He then completed a general surgery residency from 1984 to 1991 and a thoracic surgery residency from 1991 to 1993 at Duke University Medical Center. From 1993 to 1995 he completed a fellowship in Thoracic Oncology at the Dana Farber Cancer Institute associated with the Harvard Medical School. Dr. Harpole joined the faculty of Brigham and Women’s Hospital in 1993 and continued teaching there until 1996. Currently he is faculty member at Duke University, where he is a Professor of Surgery. He also is the Chief of Cardiothoracic Surgery at Virginia Medical Center in Durham, Virginia. Dr. Harpole’s research interests revolve around non-small cell lung cancer and evaluating the serum and tissue molecular biological markers patients have with recurring non-small cell lung. He is also interested in the molecular biologic staging of lymph nodes in patients and the evaluation of the clonality of metastatic tumors of patients. Dr. Harpole specializes in General Thoracic Surgery and he is interested in the diagnosing and treatment of lung cancer, esophageal cancer, and mesothelioma. He is also interested in emphysema surgery and molecular biology.

Dr. Harpole’s interest in molecular biology has led him to research the risks that cause thoracic cancer to develop. He has co-authored an article that researches the biological risk model for stage I lung cancer using the immunohistochemical analysis of patients with the use of ten molecular markers. Dr. Harpole also researches markers to see who could benefit from adjuvant chemotherapy. This could also identify patients who are at low risk for cancer recurrence that would not benefit from adjuvant chemotherapy. Along with increased use of use of molecular markers, Dr. Harpole is a proponent of using adjuvant chemotherapy after surgery.

  • Duke University Medical Center. Physician Profile.

Last modified: December 24, 2010.