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> NCT01024946

Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity

Purpose:

For patients with malignant pleural mesothelioma that has grown despite treatment with
standard chemotherapy, no treatment has yet proven beneficial. The purpose of this study is
to find out what effects, both good and bad, that everolimus has on the cancer. Everolimus
works by blocking a protein that helps the cancer grow. The goal of this clinical research
study is to learn if the study drug everolimus can shrink or slow the growth of
mesothelioma. The safety of this drug will also be studied. The patients' physical state,
changes in the size of the tumor, and laboratory findings taken during the study will help
us decide if everolimus is safe and effective.

Eligibility

Study Type: Interventional

Study Design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Official Title: Phase II Study of Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity

Additional Details:

Enrollment Size: Both

Gender: 18 Years

Min. Age: N/A

Max. Age: No

Location and Contact Information

United States, Massachusetts
Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States
Status:

United States, New York
Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States
Status:

United States, Pennsylvania
University of Pennsylvania, Philadelphia, Pennsylvania, 19104-4283, United States
Status:

Last modified: May 25, 2013.