Pemetrexed Disodium and Cisplatin Followed by Surgery With or Without Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma
This study is currently recruiting patients.
| Sponsored by: | Swiss Group for Clinical Cancer Research |
| Information provided: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00334594 |
Purpose:
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This randomized phase II trial is studying how well giving pemetrexed disodium together with cisplatin followed by surgery with or without radiation therapy works in treating patients with malignant pleural mesothelioma.
| Condition | Intervention | Phase |
|
Malignant Mesothelioma |
Drug: cisplatin Drug: pemetrexed disodium Other: laboratory biomarker analysis Procedure: adjuvant therapy Procedure: conventional surgery Procedure: neoadjuvant therapy Procedure: quality-of-life assessment Radiation: radiation therapy |
Phase 2 |
Eligibility
Study Design: Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment
Official Title: Neoadjuvant Chemotherapy and Extrapleural Pneumonectomy of Malignant Pleural Mesothelioma (MPM) With or Without Hemithoracic Radiotherapy. A Randomized Multicenter Phase II Trial
Enrollment Size: Both
Gender: 18 Years
Min. Age: 69 Years
Max. Age: No
Location and Contact Information
, D-79106
Universitaetsklinikum Freiburg, Freiburg, D-79106, Germany,
Status: Recruiting
Contact Person 49-761-270-2455
, CH-5404
Kantonsspital Baden, Baden, CH-5404, Switzerland,
Status: Recruiting
Contact Person 41-56-486-2511
, CH-4031
Universitaetsspital-Basel, Basel, CH-4031, Switzerland,
Status: Recruiting
Contact Person 41-61-265-5075
, CH-3010
Inselspital Bern, Bern, CH-3010, Switzerland,
Status: Recruiting
Contact Person 41-31-632-8169
, 3004
Spital Tiefenau, Bern 4, 3004, Switzerland,
Status: Recruiting
Contact Person 41-31-308-8111
, CH-4101
Kantonsspital Bruderholz, Bruderholz, CH-4101, Switzerland,
Status: Recruiting
Contact Person 41-61-436-3636
, CH-7000
Kantonsspital Graubuenden, Chur, CH-7000, Switzerland,
Status: Recruiting
Contact Person 41-81-256-6111
, CH-1011
Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011, Switzerland,
Status: Recruiting
Contact Person 41-21-314-4604
, CH-4600
Kantonsspital Olten, Olten, CH-4600, Switzerland,
Status: Recruiting
Contact Person 41-62-311-4241
, 4310
FMH Onkologie/Haematologie, Rheinfelden, 4310, Switzerland,
Status: Recruiting
Contact Person 41-61-836-9393
, CH-9007
Kantonsspital - St. Gallen, St. Gallen, CH-9007, Switzerland,
Status: Recruiting
Contact Person 41-71-494-1068
, 3600
Regionalspital, Thun, 3600, Switzerland,
Status: Recruiting
Contact Person 41-33-226-2645
, CH-8091
UniversitaetsSpital Zuerich, Zurich, CH-8091, Switzerland,
Status: Recruiting
Rolf A. Stahel, MD 41-1-634-2871 rolf.stahel@usz.ch
Last modified: July 29 2010.
