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Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery

Purpose:

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether combination chemotherapy is more effective with or without surgery and radiation therapy in treating mesothelioma.

PURPOSE: This randomized clinical trial is studying combination chemotherapy, surgery, and radiation therapy to see how well they work compared to combination chemotherapy alone in treating patients with mesothelioma that can be removed by surgery.

Eligibility

Study Design: Allocation: Randomized, Control: Active Control, Primary Purpose: Treatment

Official Title: Mesothelioma and Radical Surgery Trial

Enrollment Size: Both

Gender: 18 Years

Min. Age: N/A

Max. Age: No

Location and Contact Information

United Kingdom, England
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham, England, B15 2TH, United Kingdom
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United Kingdom, England
Birmingham Heartlands Hospital, Birmingham, England, B9 5SS, United Kingdom
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United Kingdom, England
Bristol Royal Infirmary, Bristol, England, BS2 8HW, United Kingdom
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United Kingdom, England
Queen's Hospital, Burton-upon-Trent, England, DE13 0RB, United Kingdom
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United Kingdom, England
Papworth Hospital, Cambridge, England, CB3 8RE, United Kingdom
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United Kingdom, England
Addenbrooke's Hospital, Cambridge, England, CB2 2QQ, United Kingdom
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United Kingdom, England
Ipswich Hospital, Ipswich, England, IP4 5PD, United Kingdom
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United Kingdom, England
Cookridge Hospital, Leeds, England, LS16 6QB, United Kingdom
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United Kingdom, England
Leicester Royal Infirmary, Leicester, England, LE1 5WW, United Kingdom
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United Kingdom, England
Glenfield Hospital, Leicester, England, LE3 9QP, United Kingdom
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United Kingdom, England
Royal Marsden - London, London, England, SW3 6JJ, United Kingdom
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United Kingdom, England
St. Thomas' Hospital, London, England, SE1 9RT, United Kingdom
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United Kingdom, England
Nottingham City Hospital NHS Trust, Nottingham, England, NG5 1PB, United Kingdom
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United Kingdom, England
Berkshire Cancer Centre at Royal Berkshire Hospital, Reading, England, RG1 5AN, United Kingdom
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United Kingdom, England
Cancer Research Centre at Weston Park Hospital, Sheffield, England, S1O 2SJ, United Kingdom
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United Kingdom, England
Royal Marsden - Surrey, Sutton, England, SM2 5PT, United Kingdom
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United Kingdom, England
Institute of Cancer Research - Sutton, Sutton, England, SM2 5NG, United Kingdom
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Last modified: July 29 2010.